产品说明
一般描述
Cytosolic sulfotransferase (ST) enzymes catalyze the sulfate conjugation of many drugs, xenobiotic compounds, hormones, and neurotransmitters. Sulfotransferases such as SULT1B1 catalyze the biotransformation of a large number of endogenous compounds such as neurotransmitters, steroids, bile acids, and thyroid hormones, as well as drugs and xenobiotics. SULT1B1 contains a binding site for the sulfate donor, 3-prime-phosphoadenosine 5-prime-phosphosulfate, and a cysteine residue conserved in the ST1 gene family of sulfotransferases. SULT1B1 shares between 51.5% and 56.3% amino acid sequence identity with members of the phenol sulfotransferase gene family. Northern blot analysis detects 4 SULT1B1 transcripts between 79 kb and 13 kb expressed at highest levels in liver, peripheral blood leukocytes, colon, small intestine, and spleen. Lower expression is detected in lung, placenta, and thymus, and no expression is detected in other tissues. Recombinant rat and human SULT1B1, expressed in E. coli, catalyze sulfation of p-nitrophenol, 3,3-prime,5-triiodothyronine (T3), and dopamine, but not of beta-estradiol and dehydroepiandrosterone. SULT1B1 shows higher affinities for formation of T3 sulfate than do the phenol sulfotransferases ST1A3 (SULT1A1) or ST1A5. Bacterially-expressed SULT1B1 sulfates small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3-prime-diiodothyronine, triiodothyronine, reverse triiodothyronine, and thyroxine. No activity is detected against several sterols or dopamine.
免疫原
SULT1B1 (NP_055280, 1-30)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human SULT1B1.
外形
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | mouse, human |
| technique(s) | indirect ELISA: 1:1000 western blot: 1:100-1:500 |
| NCBI登记号 | NP_055280 |
| UniProt登记号 | O43704 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... SULT1B1(27284) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
