产品说明
一般描述
SUMO1 (small ubiquitin-related modifier), also called as Pic1 (inner centromere protein-related protein), Ubl1 (ubiquitin-like protein), hSmt3 (human homolog 3), or sentrin, is mainly expressed in the nucleus. The gene encoding SUMO1 is mapped to human chromosome 2q33. SUMO1 belongs to ubiquitin-like protein family and it consists of 101 amino acids.
Monoclonal Anti-Sumo-1 (rat IgG2a isotype) is derived from the hybridoma 4D12 produced by the fusion of mouse myeloma cells (SP2/0) and splenocytes from rat immunized with a fusion protein of human SUMO1.
免疫原
fusion protein of human SUMO1
应用
Monoclonal Anti-Sumo-1 has been used in immunocytochemistry.
Monoclonal Anti-Sumo-1 has been used in western blotting.
生化/生理作用
Suppressing SUMO1 (small ubiquitin-related modifier) inhibits multiplication and induces apoptosis of gastric cancer SGC-7901 cells. It is essential for HCV (hepatitis C virus) replication. Deletion of SUMO1 blocks the aggregation of lipid droplets. It is also implicated in mitochondrial fission.
Sumo-1 interacts with dsDNA and competes with other protein-DNA interactions.
外形
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD02096449 |
| NACRES | NA.41 |
产品性质
| 偶联物 | unconjugated |
| 抗体形式 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| 克隆 | 4D12, monoclonal |
| 形式 | buffered aqueous solution |
| 分子量 | ~12 kDa |
| species reactivity | mouse, human, rat |
| 浓度 | ~1.0 mg/mL |
| technique(s) | immunocytochemistry: suitable western blot: 2-4 μg/mL using HeLa cell extracts |
| 同位素/亚型 | IgG2a |
| UniProt登记号 | P63165 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... SUMO1(7341) mouse ... Sumo1(22216) rat ... Sumo1(301442) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
