产品说明
一般描述
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
免疫原
A phospho synthetic peptide corresponding to residues surrounding S441 of Mouse MLKL.
外形
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
产品性质
生物来源 | rabbit |
质量水平 | 100 |
antibody product type | primary antibodies |
克隆 | polyclonal |
形式 | liquid |
species reactivity | rat |
浓度 | 0.238 mg/mL |
technique(s) | western blot: 1:500-1:2000 |
UniProt登记号 | Q9D2Y4 |
运输 | wet ice |
储存温度 | −20℃ |
Gene Information | mouse ... MLKL(74568) |
安全信息
闪点(F) | Not applicable |
闪点(C) | Not applicable |