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Anti-phospho-Nuclear Receptor NR4A1 (pSer351) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4301270
规格纯度
affinity isolated antibody
参考价格
6141.35 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Nuclear receptor subfamily 4 group A member 1 (NR4A1) also known as nuclear hormone receptor 77 (NUR77), belongs to NR4A subfamily nuclear hormone receptors. In human chromosome, the gene NR4A1 is localized on 12q13.13.

特异性

The antibody detects endogenous levels of Nuclear Receptor NR4A1 only when phosphorylated at serine 351

免疫原

Peptide sequence around phosphorylation site of Serine351(L-P-S(p)-K-P) derived from Human Nuclear Receptor NR4A1.

生化/生理作用

Nuclear receptor subfamily 4 group A member 1 (NR4A1) is essential for regulation of cell proliferation, apoptosis and energy metabolism. Nur77 is an acetylated protein, modulated by histone acetyltransferase p300 (p300) and histone deacetylase 1 (HDAC1) for its rapid turnover. Nur77 regulates liver kinase B1 (LKB1)- AMP (adenosine monophosphate)-activated protein kinase (AMPK) and plays a major role in glucose metabolism. Expression of Nur77 in skeletal muscle promotes glucose uptake by enhancing insulin pathway and upregulates glycolysis pathway. Expression of Nur77 in hepatocytes promotes gluconeogenesis. Mutation in Nur77 may result in diet-induced obesity and insulin resistance in tissues. Nur77 is a potential drug target for metabolic disorders. NR4A1 is an anti-oncogenic protein that reduces the tumour cell proliferation and metastasis. NR4A1 increases the gastric cancer cells sensitivity towards tumour necrosis factor α (TNF-α) mediated apoptotic pathway. NR4A1 is downregulated in breast cancer, leukemia. NR4A1 plays a crucial role and a potent therapeutic target for fibrosis of endometriosis.

特点和优势

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外形

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 64 kDa
species reactivitymouse, rat, human
浓度1.0 mg/mL
technique(s)immunohistochemistry: 1:50-1:100
同位素/亚型IgG
登记号NP_002126.2.
UniProt登记号P22736
运输wet ice
储存温度−20℃
Gene Informationhuman ... NR4A1(3164)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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