产品说明
一般描述
Potassium calcium activated channel subfamily M regulatory β subunit 4 (KCNMB4) is mapped to human chromosome 12q14.1-15. The encoded protein is a member of the potassium channel β subunit family. KCNMB4 contains two transmembrane segments (TM1 and TM2), intracellular N and C terminal and a large extracellular loop. It is mainly expressed in the brain, neuronal tissue, kidney and bladder smooth muscle.
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. (provided by RefSeq)
免疫原
KCNMB4 (NP_055320.4, 1 a.a. ~ 210 a.a) full-length human protein.
Sequence
MAKLRVAYEYTEAEDKSIRLGLFLIISGVVSLFIFGFCWLSPALQDLQATEANCTVLSVQQIGEVFECTFTCGADCRGTSQYPCVQVYVNNSESNSRALLHSDEHQLLTNPKCSYIPPCKRENQKNLESVMNWQQYWKDEIGSQPFTCYFNQHQRPDDVLLHRTHDEIVLLHCFLWPLVTFVVGVLIVVLTICAKSLAVKAEAMKKRKFS
生化/生理作用
Potassium calcium activated channel subfamily M regulatory α subunit 4 (KCNMB4) plays a vital role in increasing Ca2+ sensitivity. It reduces the voltage dependence of the conductance-voltage relationship as well as the slope of the gating charge-voltage curve.
外形
Solution in phosphate buffered saline, pH 7.4
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~23.9 kDa |
| species reactivity | human |
| technique(s) | western blot: 1 μg/mL |
| NCBI登记号 | NM_014505 |
| UniProt登记号 | Q86W47 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... KCNMB4(27345) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
