Anti-FANCC Antibody, clone 8F3

产品说明

一般描述

Fanconi anemia (FA) is an inherited bone marrow failure syndrome associated with a progressive decline in hematopoietic stem cells, developmental defects, and predisposition to cancer. FANCC is part of the multisubunit Fanconi anemia (FA) complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. FANCC is a primarily nuclear localized DNA repair protein that is believed to function in interstrand DNA cross-link repair and the maintenance of normal chromosome stability. Mutations in FANCC are associated with various aspects of FA. New research shows that FANCC is critical for resistance to DNA cross-linking drug-induced DNA damage in cells patients with myeloproliferative neoplasms. Also, FANCC interacts with the C-terminal-binding protein-1 (CtBP1) involved in transcriptional regulation, including being a negative regulator of Dickkopf-1 (DKK1) expression. This down regulation does not occur in mutations of FANCC, which then leads to up-regulation of DKK1, a molecule involved in hematopoietic malignancies.

免疫原

Linear peptide corresponding to Human FANCC.

应用

This Anti-FANCC Antibody, clone 8F3 is validated for use in Western Blotting and Immunoprecipitation and Immunocytochemistry for the detection of FANCC.
Research Sub Category
Apoptosis - Additional
Western Blotting Analysis: 4 µg/mL of a representative lot of this antibody detected FANCC in 10 µg of Mouse brain lysate.

Western Blotting Analysis: A representative lot detected FANCC in HeLa cell lysate (Tremblay, C.S., et al. (2008) Blood. 112(5):2062-2070).

Immunoprecipitation Analysis: A representative lot immunoprecipitated FANCC from HeLa cell lysate (Tremblay, C.S., et al. (2008) Blood. 112(5):2062-2070).

Immunocytochemistry Analysis: A representative lot detected FANCC in HeLa cells (Tremblay, C.S., et al. (2008) Blood. 112(5):2062-2070).
Research Category
Apoptosis & Cancer

质量

Evaluated by Western Blotting in PC12 cell lysate.

Western Blotting Analysis: 4 µg/mL of this antibody detected FANCC in 10 µg of PC12 cell lysate.

目标描述

~ 63 kDa observed

外形

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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