产品说明
一般描述
CASK (Calcium/calmodulin-dependent serine protein kinase) interacting protein 1 (CASKIN1) is expressed in the neuronal cells. The N terminal region of Caskin1 have six ankyrin repeats, two sterile α motifs (SAM domains) and a single SH3 domain. The C-terminal region possesses a long proline-rich region. In human chromosome, the gene CASKIN1 is localized on 16p13.3.
生化/生理作用
CASK interacting protein 1 (CASKIN1) is a scaffold protein involved in synapses. Caskin1 interacts with Calcium/calmodulin-dependent serine protein kinase (Cask) in the CASK interaction domain (CID) adjacent to SAM domain. Caskin1 also interacts with Nck (non-catalytic region of tyrosine kinase adaptor protein 1)/Dock (dedicator of cytokinesis), neurexin2, synaptotagmin, and septin4. Caskin1 interacts with EphB1 (ephrinB ligands) through Nck adapter protein. The interaction phosphorylates the tyrosine residue in the SH3 domain and causes changes in the SH3 domain. Caskin1 forms a tripartite complex with Cask/caskin1/velis. Caskin1 competes with Munc-interacting protein 1 (Mint1) to form the tripartite complex. The tripartite complex binds to the cytoplasmic tail of neurexin, which is enriched in the presynaptic sites.
特点和优势
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联系
The action of this antibody can be blocked using blocking peptide SBP3500780.
外形
Supplied at 1 mg/mL in PBS with 0.02% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | predicted mol wt 157 kDa |
| species reactivity | human |
| technique(s) | ELISA: suitable western blot: suitable |
| UniProt登记号 | Q8WXD9 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... CASKIN1(57524) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
