产品说明
一般描述
P40, also known as Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor , KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, or p51, and encoded by the gene TP63/KET/P63/P73H/P73L/TP73L, is a transcriptional activator or repressor depending upon the target gene and the isoform involved. P40 has multiple isoforms. P40 is involved in Notch signaling and plays a role in p53/TP53 dependent apoptosis and epithelial morphogenesis. Moreover P40, developmentally, is required for proper limb formation. P40 is widely expressed in the adult and during development. Some isoforms, such as isoform 10 are primarily expressed in cancerous tissues while others are found only in normal tissues. Mutations in P40 lead to a variety of dysplasias and malformations, including Acro-dermato-ungual-lacrimal-tooth syndrome and Ankyloblepharon-ectodermal defects cleft lip/palate disorder and several more tragic disfiguring syndromes.
免疫原
KLH-conjugated linear peptide corresponding to human P40.
应用
Immunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected P40 in human prostate and human kidney tissue.
Research Category
Signaling
Research Sub Category
Signaling Neuroscience
Anti-P40 Antibody, clone 11F12.1 is an antibody against P40 for use in IHC (Paraffin) & western blotting.
质量
Evaluated by Western Blotting in SK-OV-3 cell lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected P40 in 10 µg of SK-OV-3 cell lysate.
目标描述
~40 kDa observed
外形
Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Protein G Purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
其他说明
Concentration: Please refer to lot specific datasheet.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 11F12.1, monoclonal |
| species reactivity | human |
| technique(s) | immunohistochemistry: suitable (paraffin) western blot: suitable |
| 同位素/亚型 | IgG2aκ |
| NCBI登记号 | NP_001108450 |
| UniProt登记号 | Q9H3D4 |
| 运输 | wet ice |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
