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Anti-PGR (Ab-190) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300348
规格纯度
affinity isolated antibody
参考价格
4578.18 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

免疫原

Peptide sequence around aa. 188-192 (G-L-S-P-A), according to the protein PGR.

特点和优势

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目标描述

Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid,glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-kappaB, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition,progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD00239723
NACRESNA.41

产品性质

生物来源rabbit
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 ~99 kDa
species reactivityhuman
浓度1 mg/mL
technique(s)indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
同位素/亚型IgG
免疫原序列(G-L-S-P-A)
NCBI登记号NP_000917.3
UniProt登记号P06401
运输wet ice
储存温度−20℃
Gene Informationhuman ... PGR(5241)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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