产品说明
一般描述
JAK2 (janus kinase 2) encodes a tyrosine kinase. It belongs to the the Jak family of protein. It is located on chromosome 9p24.
免疫原
Peptide sequence around aa. 568-572 (G-D-Y-G-Q), according to the protein JAK2.
生化/生理作用
JAK2 (janus kinase 2) plays an important role in the activities of cytokines receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy.
特点和优势
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目标描述
Plays a role in leptin signaling and control of body weight.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
产品性质
| 生物来源 | rabbit |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | ~125 kDa |
| species reactivity | human, rat |
| 浓度 | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 |
| 同位素/亚型 | IgG |
| 免疫原序列 | (G-D-Y-G-Q) |
| NCBI登记号 | NP_004963.1 |
| UniProt登记号 | O60674 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... JAK2(3717) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
