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Anti-MAP2K4 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4300707
规格纯度
affinity isolated antibody
参考价格
5001.78 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The antibody detects endogenous levels of total MAP2K4 protein.

免疫原

Peptide sequence around aa. 352-356 (E-S-K-R-P), according to the protein NP_003001.1

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

目标描述

SAPK/Erk kinase (SEK1), also known as MKK4 or Jun kinase kinase (JNKK), activates the MAP kinase homologues SAPK and JNK in response to various cellular stresses and inflamatory cytokines (1-3). Activation of SEK1 occurs through MEKK phosphorylation of serine and threonine residues at positions 257 and 261, respectively. Like MEK, SEK is a dual-specificity protein kinase that phosphorylates SAPK/JNK at a conserved T*PY* site in its activation loop (4). Phosphorylation by Akt at Ser80 inhibits SEK1 and suppresses stress-activated signal transduction (5).

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

基本信息

NACRESNA.41

产品性质

生物来源rabbit
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量 ~44 kDa
species reactivitymouse, human, rat
浓度1 mg/mL
technique(s)western blot: 1:500-1:1000
同位素/亚型IgG
免疫原序列(E-S-K-R-P)
NCBI登记号NM_003010.2
UniProt登记号P45985
运输wet ice
储存温度−20℃
Gene Informationhuman ... MAP2K4(6416)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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