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Flt-3 Ligand human

品牌
Sigma-Aldrich
货号
SRP3044
规格纯度
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
参考价格
5617.33 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

FLT3LG (Fms-related tyrosine kinase 3 ligand) is a transmembrane glycoprotein and a ligand for FLT3 receptor. It is widely expressed in human tissues. The protein exists in membrane bound as well as secreted forms. Binding of FLT3LG to FLT3 results in receptor dimerization, activation of the tyrosine kinase domain, autophosphorylation and thereby activation of the receptor. Recombinant human Flt3-Ligand is a soluble 17.6kDa protein consisting of 155 amino acid residues.

生化/生理作用

FLT3LG (Fms-related tyrosine kinase 3 ligand) is a hematopoietic growth factor. It plays a significant role in the development of myeloid and plasmacytoid dendritic cells. It is also involved in the expansion of Treg (T regulatory) cells, thereby offering treatment for autoimmune disorders and transplantation processes. FLT3LG is associated with autoimmune arthritis, for instance rheumatoid arthritis and primary Sjogren′s syndrome. FLT3LG along with FLT3 is involved in the proliferation of primary AML (acute myeloid leukemia) blasts and autocrine signaling in AML.

序列

MTQDCSFQHS PISSDFAVKI RELSDYLLQD YPVTVASNLQ DEELCGGLWR LVLAQRWMER LKTVAGSKMQ GLLERVNTEI HFVTKCAFQP PPSCLRFVQT NISRLLQETS EQLVALKPWI TRQNFSRCLE LQCQPDSSTL PPPWSPRPLE ATAPT

外形

Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, 50 mM NaCl, pH 7.5

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in E. coli
测定≥98% (HPLC)
≥98% (SDS-PAGE)
形式lyophilized
效能≤10 ng/mL ED50 ((OCI-AML5 cell proliferation))
分子量 17.6 kDa
包装pkg of 10 μg
technique(s)cell culture | mammalian: suitable
杂质<0.1 EU/μg endotoxin, tested
颜色 white to off-white
UniProt登记号P49771
运输wet ice
储存温度−20℃
Gene Informationhuman ... FLT3LG(2323)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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