产品说明
一般描述
IL-34 is a ligand for colony-stimulating factor-1 receptor (CSF1R), which also binds to CSF-1. It specifically binds CD14+ monocytes, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. IL-34, like human CSF-1 stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1.
生化/生理作用
IL-34 is a homodimeric cytokine that is expressed in a range of tissues including spleen, heart, brain, liver, kidney, lung, ovary, thymus, testis, small intestine, prostate and colon. Recombinant human IL-34 is a 52.5 kDa homodimeric glycoprotein consisting of 460 amino acid residues, including a C-terminal His-Tag.
外形
Lyophilized from 20 mM Sodium Citrate, pH 3.0 + 75 mM NaCl.
重悬
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.
基本信息
NACRES | NA.32 |
产品性质
生物来源 | human |
重组 | expressed in HEK 293 cells |
测定 | ≥95% (HPLC) ≥95% (SDS-PAGE) |
形式 | lyophilized |
分子量 | 52.5 kDa |
包装 | pkg of 10 μg |
杂质 | <0.1 EU/μg endotoxin, tested |
UniProt登记号 | Q6ZMJ4 |
运输 | wet ice |
储存温度 | −20℃ |
Gene Information | human ... IL34(146433) |
安全信息
象形图 | |
警示用语: | Warning |
危险声明 | H319 |
预防措施声明 | P264 - P280 - P305 + P351 + P338 - P337 + P313 |
危险分类 | Eye Irrit. 2 |
储存分类代码 | 12 - Non Combustible Liquids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |