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Ubiquitin Carrier Protein H3/CDC34 human

品牌
Sigma-Aldrich
货号
U2383
规格纯度
≥95% (SDS-PAGE), recombinant, expressed in E. coli overproducing strain
参考价格
6313.46 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Infected cell protein 0 of herpes simplex virus 1 was shown to bind UbcH3 and induce its degradation by promoting its polyubiquination. This resulted in increased expression of an UbcH3-target gene cyclin D1 and aided in further viral infection.
Cdc34 is an essential gene for viability in yeast. Cdc34 mediates the transition from G1 to S-phase of the cell cycle by degrading the S-phase cyclin/CDK inhibitor, SIC1 in yeast and p27(KIP1) in human. Cdc34 is also known to interact with the Skp1/Cdc53/F-box (SCF) ubiquitin ligase subunits Cul1 to degrade the NF-κB inhibitor IκBα in a phosphorylation-dependent manner.

外形

Solution in 50 mM HEPES, 200 mM NaCl, 1 mM TCEP (pH 7.5), and 10% glycerol.

其他说明

Manufactured for Sigma by Boston Biochem. Inc.

基本信息

MDL编号MFCD03101856
NACRESNA.56

产品性质

质量水平200
生物来源human
重组expressed in E. coli overproducing strain
测定≥95% (SDS-PAGE)
形式solution
分子量 ~32 kDa
UniProt登记号P49427
P61088
application(s)cell analysis
运输dry ice
储存温度−70℃
Gene Informationhuman ... CDC34(997), UBE2N(7334)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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