产品说明
应用
Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.
包装
5 mg in glass bottle
25 mg in poly bottle
生化/生理作用
Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor that can induce apoptosis in cancer cells, inhibit the growth of vascular smooth cells and block calcium release-dependent phosphorylations.
特点和优势
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制备说明
Tyrphostin A9 is soluble in ethanol at 20 mg/ml, in DMSO at a concentration less than 25 mg/ml. It is insoluble in water.
基本信息
| 经验(实验)分子式 | C18H22N2O |
| 分子量 | 282.38 |
| MDL编号 | MFCD00209853 |
| PubChem化学物质编号 | 24278069 |
| NACRES | NA.77 |
产品性质
| 生物来源 | synthetic (organic) |
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| 颜色 | yellow |
| mp | 139-140 ℃ |
| 溶解性 | ethanol: 20 mg/mL DMSO: <25 mg/mL H2O: insoluble |
| SMILES string | CC(C)(C)c1cc(\C=C(\C#N)C#N)cc(c1O)C(C)(C)C |
| InChI | 1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3 |
| InChI key | MZOPWQKISXCCTP-UHFFFAOYSA-N |
| Gene Information | human ... EGFR(1956), ORAI1(84876), PDGFRA(5156), PDGFRB(5159) mouse ... Eef2k(13631), Prkaca(18747), Prkca(18750), Src(20779) |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H301 + H311 |
| 预防措施声明 | P280 - P301 + P310 + P330 - P302 + P352 + P312 |
| 危险分类 | Acute Tox. 3 Dermal - Acute Tox. 3 Oral |
| 储存分类代码 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
