产品说明
一般描述
Lysophosphatidic acid (LPA) belongs to a class of phospholipids, that has a glycerol backbone attached by a phosphate group, an aliphatic chain and a hydroxyl group. It has a phosphate group attached to sn-3 position, an aliphatic chain attached to sn-1 or sn-2 position and the hydroxyl group attached to the remaining sn-1 or sn-2 position. 06:0 Lyso PA/HHGP, belongs to the LPA (lysophosphatidic acid) family. It is a negatively charged single chain lipid.
Lysophosphatidic acid (LPA) has a free hydroxyl and phosphate moiety. It is hydrophilic and is not associated with the membrane. It is the major constituent of serum.
应用
06:0 Lyso PA (LPA) has been used in the structure-activity relationship (SAR) analysis with G-protein receptor GPR92. It has also been used in lipid assay in the treatment of serum-starved primary mouse embryonic fibroblast cells.
06:0 Lyso PA has been used to study the role of lipid binding to MxiM protein in co‐crystallization experiments.
生化/生理作用
Lysophosphatidic acid (LPA) participates in several biological functions. LPA stimulates platelet aggregation, chemotaxis, cytoskeleton rearrangement, Ca2+ mobilization and cell proliferation. 06:0 Lyso PA/HHGP possesses a micromolar binding affinity for global regulator of LEE (locus of enterocyte effacement) repressor (GrlR) and for β-lactoglobulin.
Lysophosphatidic acid (LPA) is the precursor for the synthesis of phospholipids in eukaryotes and prokaryotes. It acts as an intercellular signaling molecule. Activated platelets produce LPA. It plays a major role in tissue healing and wound regeneration. LPA binds to G-protein coupled receptors. It possesses mitogenic properties. LPA inhibits differentiation of neuroblastoma and myoblast, aids in neurotransmitter release and smooth muscle contraction. It is a potential biomarker for ovarian and gynecological cancers. It is implicated in the initiation of neuropathic pain.
包装
5 mL Amber Glass Screw Cap Vial (857119P-25mg)
基本信息
| 经验(实验)分子式 | C9H22NO7P |
| 分子量 | 287.25 |
| NACRES | NA.25 |
产品性质
| 测定 | >99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC) |
| 形式 | powder |
| 包装 | pkg of 1 × 25 mg (857119P-25mg) |
| manufacturer/tradename | Avanti Polar Lipids 857119P |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| SMILES string | O[C@](COP([O-])(O)=O)([H])COC(CCCCC)=O.[NH4+] |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
