产品说明
一般描述
Protein tyrosine phosphatase, receptor type B (PTPRB), also known as vascular endothelial-protein-tyrosine phosphatase (VE-PTP), might have a role in remodeling of blood vessels and in angiogenesis. The gene encoding it is localized on human chromosome 12q15. It is also important for endothelial cell migration. The protein also controls the phosphorylation state of the angiopoietin receptor, Tie-2. PTPRB may modulate sodium channels by influencing the tyrosine phosphorylation status.
生化/生理作用
Dephosphorylates tyrosine proteins.
单位定义
One unit of PTP-β will hydrolyze 1.0 nanomole of p-nitrophenyl phosphate per min at 30 ℃.
外形
solution in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCL, 3 mM DTT, 16 mM glutathione and 20% glycerol
基本信息
| MDL编号 | MFCD02688688 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 生物来源 | human |
| 重组 | expressed in E. coli K12 |
| 测定 | ≥90% |
| 形式 | buffered aqueous glycerol solution |
| specific activity | ≥50,000 units/mg protein |
| 分子量 | ~250 kDa |
| UniProt登记号 | P23467 |
| application(s) | cell analysis |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... PTPRB(5787) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
