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Pilsicainide Hydrochloride

吡西卡尼 盐酸盐

品牌
Sigma-Aldrich
货号
P0026
规格纯度
≥98% (HPLC)
参考价格
944.89 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Pilsicainide hydrochloride has been used as a sodium channel blocker:

  • to study its effects on electrophysiological parameters in guinea pig pulmonary vein preparation
  • to study its effects on Ca2+ release and arrhythmic events in Andersen-Tawil syndrome induced pluripotent stem cells (ATS-iPSC)-derived cardiomyocytes
  • to study its electrophysiological effects on the guinea pig atrium

包装

10, 50 mg in glass bottle

生化/生理作用

Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na+1 channels. Pilsicainide was defined as a pure sodium channel blocker. The compound is classified as a class Ic antiarrhythmic drug, and was originally developed in Japan. Similar to Lidocaine, Pilsicainide binds to open channels, but slowly. Pilsicainide is capable of selectively blocking the late currents in the mutant Na(+) channels that show dominant abnormal burst openings such as in δKPQ mutants. The compound is used to induce Brugada syndrome (BS) in animal models.

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

经验(实验)分子式C17H24N2O · xHCl
分子量272.39 (free base basis)
MDL编号MFCD00903769
PubChem化学物质编号329819981

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性deionized water: >5 mg/mL
储存温度room temp
SMILES stringCl.Cc1cccc(C)c1NC(=O)CC23CCCN2CCC3
InChI1S/C17H24N2O.ClH/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17;/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20);1H
InChI keyNZOSVDHCTCLGEB-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
危险分类Acute Tox. 4 Oral
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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