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Phenserine

品牌
Sigma-Aldrich
CAS
101246-66-6
货号
P0111
规格纯度
≥98% (HPLC), solid
参考价格
1341.59 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

25, 100 mg in glass bottle

生化/生理作用

(-)-Phenserine, a phenylcarbamate derivative, is a selective, non-competitive inhibitor of acetylcholinesterase (AChE). (-)-Phenserine produces rapid, potent, and long-lasting AChE inhibition, in vivo. It is significantly less toxic than (-)-physostigmine. (-)-Phenserine improves cognitive performance in both young learning-impaired and elderly rats. Reduced secretion of β-amyloid (Abeta) has been observed in cell lines exposed to (-)-phenserine, occurring through translational regulation of β-amyloid precursor protein (beta-APP) mRNA via a non-cholinergic mechanism. These in vitro findings appear to translate in vivo into animal models and humans.

特点和优势

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式C20H23N3O2
分子量337.42
MDL编号MFCD00672748
PubChem化学物质编号329820018
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
颜色 off-white
溶解性H2O: <2 mg/mL
DMSO: >5 mg/mL
储存温度2-8℃
SMILES string[H][C@]12N(C)CC[C@@]1(C)c3cc(OC(=O)Nc4ccccc4)ccc3N2C
InChI1S/C20H23N3O2/c1-20-11-12-22(2)18(20)23(3)17-10-9-15(13-16(17)20)25-19(24)21-14-7-5-4-6-8-14/h4-10,13,18H,11-12H2,1-3H3,(H,21,24)/t18-,20+/m1/s1
InChI keyPBHFNBQPZCRWQP-QUCCMNQESA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319 - H335
预防措施声明P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

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