产品说明
一般描述
Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.
Phosphatidylinositol 4,5-bisphosphate (PIP2) is a negatively charged phospholipid, abundant in the plasma membrane.
应用
18:0-20:4 PI(4,5)P2 or 1-stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1′-myo-inositol-4′,5′-bisphosphate) (ammonium salt) has been used:
- in cryo-electron microscopy (cryo-EM) grid preparation
- in host 1-O-1-(Z)-octadecenyl-2-arachidonoyl-sn-glycero-3-phosphocholine (plasmenyl-SAPC) small unilamellar vesicles (SUVs) in the presence of H2O2 to activate cyt c plasmalogenase activity
- to study whether acyl chain types affect phosphatidylinositol 4,5-bisphosphate (PIP2) cluster formation
包装
2 mL Amber Serum Vial with Stopper and Crimp Cap (850165P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850165P-500ug)
基本信息
| 经验(实验)分子式 | C47H94N3O19P3 |
| 分子量 | 1098.18 |
| NACRES | NA.25 |
产品性质
| 测定 | >99% (TLC) |
| 形式 | powder |
| 包装 | pkg of 1 × 100 μg (with stopper and crimp cap (850165P-100ug)) pkg of 1 × 500 μg (with stopper and crimp cap (850165P-500ug)) |
| manufacturer/tradename | Avanti Polar Lipids 850165P |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| SMILES string | [H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1O)=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+] |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
