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14:0 Cardiolipin (ammonium salt)

1,1′,2,2′-tetramyristoyl cardiolipin (ammonium salt); 1,1′,2,2′-tetratetradecanoyl cardiolipin (ammonium salt); CL(1′-[14:0/14:0],3′-[14:0/14:0])

品牌
Avanti
CAS
63988-20-5
货号
710332P
规格纯度
1′,3′-bis[1,2-dimyristoyl-sn-glycero-3-phospho]-glycerol (ammonium salt), powder
参考价格
1260.58 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

14:0 Cardiolipin or TMCL (1,1′,2,2′-tetramyristoyl cardiolipin) is a saturated CL and exists as gel at low temperatures.
Cardiolipin is an anionic phospholipid. The 14:0 indicates the fatty acyl substituents attached to the carbons of glycerol. It is localized to the inner mitochondrial membrane.

应用

14:0 Cardiolipin (ammonium salt) has been used as stable isotope-labeled standard prior to yeast strains high performance liquid chromatography electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS). It may be used as an internal standard in mass spectroscopy and in liposome preparation for electrophysiological studies.
14:0 Cardiolipin (ammonium salt) may be used in lipopeptide synthesis.

生化/生理作用

TMCL (1,1′,2,2′-tetramyristoyl cardiolipin) bilayers are useful in generating multilamellar vesicles. Defects in the cardiolipin metabolic associated with Barth syndrome patients. Liposomes of TMCL with 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and cholesterol are potential drug-delivery systems. TMCL displays temperature dependent thermotropic phase transitions.
Cardiolipin participates in proton uptake pathway and also maintains the structure of enzymes involved. Cardiolipin maintains the mitochondrial function, membrane potential and structural support for the inner mitochondrial membrane and proteins in it. Concentration and composition changes of cardiolipin have been implicated in pathological conditions including ischemia, hypothyroidism, aging, heart failure and cardioskeletal myopathy.) Cardiolipin can form micelles/vesicles naturally.

包装

5 mL Amber Glass Screw Cap Vial (710332P-25mg)
5 mL Amber Glass Screw Cap Vial (710332P-200mg)

基本信息

经验(实验)分子式C65H132N2O17P2
分子量1275.69
NACRESNA.25

产品性质

测定>99% (TLC)
形式powder
包装pkg of 1 × 200 mg (710332P-200mg)
pkg of 1 × 25 mg (710332P-25mg)
manufacturer/tradenameAvanti Polar Lipids 710332P
运输dry ice
储存温度−20℃

安全信息

储存分类代码13 - Non Combustible Solids

Sigma-Aldrich

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