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Anti-Potassium Channel KIR3.2 (GIRK2) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
P8122
规格纯度
affinity isolated antibody, lyophilized powder
参考价格
4731.57 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

G protein-activated inward rectifier potassium channel 2 (GIRK2) is localized on the plasma membrane. It is expressed majorly in the brain and to some extent in the pancreas. The GIRK2 gene is mapped to human chromosome 21q22.13. Structurally, GIRK2 exists as a tetramer and comprises a transmembrane domain and a cytoplasmic domain.

特异性

Anti-Potassium Channel KIR3.2 (GIRK2) recognizesKIR3.2 (GIRK2).

免疫原

GST fusion protein with sequence corresponding to residues 374-414 of mouse KIR3.2 (GIRK2). Sequence homology is 40/41, 39/41, and 37/41 residues identical in rat, golden hamster, and human, respectively.

应用

Anti-Potassium Channel KIR3.2 (GIRK2) antibody produced in rabbit has been used in:

  • immunoblotting
  • immunofluorescence
  • immunocytochemistry

生化/生理作用

G protein-activated inward rectifier potassium channel 2,(GIRK2) plays a key role in γ-aminobutyric acid-ergic (GABAergic), dopaminergic, cholinergic, and glutamatergic synapses. It also regulates neuronal excitability. GIRK2 through G protein-coupled receptor stimulation modulates neuronal circuit activity and heart rate in cardiac cells. Deletion of the GIRK2 gene in mice may lead to an anxiety-like phenotype and a depression-resistant behavior.

外形

Lyophilized powder from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD07370454
NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式lyophilized powder
species reactivitymouse, rat
technique(s)western blot: 1:200 using rat brain membranes
UniProt登记号P48550
运输dry ice
储存温度−20℃
Gene Informationhuman ... KCNJ6(3763)
mouse ... Kcnj6(16522)
rat ... Kcnj6(25743)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2

Sigma-Aldrich

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