位置:首页 > 品牌 > Sigma-Aldrich >

p53 human

品牌
Sigma-Aldrich
货号
P6249
规格纯度
recombinant, expressed in E. coli, buffered aqueous glycerol solution
参考价格
7882.02 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

p53 is regulated by MDM2, which acts as a negative regulator of p53 transcription by promoting its degradation by functioning as an E3 ubiquitin ligase which recognizes the N′ terminal transactivation domain.

应用

Useful for the study of postranslational modification of p53, or protein-protein interaction studies.

生化/生理作用

p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer.

物理属性

GST-tagged, full-length human p53

基本信息

NACRESNA.25

产品性质

质量水平200
生物来源human
重组expressed in E. coli
测定≥85% (SDS-PAGE)
形式buffered aqueous glycerol solution
UniProt登记号P04637
application(s)genomic analysis
运输wet ice
储存温度−20℃
Gene Informationhuman ... TP53(7157)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号