位置:首页 > 品牌 > Sigma-Aldrich >

Anti-NUMB (C-terminal) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
N6539
规格纯度
~1.0 mg/mL, affinity isolated antibody
参考价格
4731.57 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Numb gene with 13 exons is mapped to human chromosome 14q24.3. The protein comprises 651 amino acids. It belongs to the clathrin-associated sorting protein family with two domains namely phosphotyrosine-binding (PTB) and proline-rich region (PRR) domain. Mammalian Numb gene gives rise to at least four alternatively spliced transcripts that produce four protein isoforms Numb1-4, ranging from 65 to 72 kDa.
Numb homolog-NUMB is an adaptor protein and is aberrantly expressed in cancers.

应用

Anti-NUMB (C-terminal) antibody produced in rabbit has been used in immunoblotting.

生化/生理作用

Numb homolog-NUMB may act as a tumor suppressor. It also takes part in determining the cell fate. NUMB is involved in the endocytosis and trafficking of receptors.
Numb is a critical Notch antagonist and a conserved adapter protein that plays a role in the self-renewal of NSCs and neural differentiation in the central nervous system (CNS). In neural progenitors of CNS, the functional loss of numb is implicated in embryonic lethality accompanied by precocious neuronal differentiation. It has been suggested that a switch in numb isoform expression is a critical step in cortical development. Numb1 or numb3 isoforms that contain an insertion in the proline-rich region (PRRL), promote the proliferation of neural crest stem cells (NCSCs). Numb2 or numb4 isoforms without PRR insertions (PRRS) show ectopic expression and promote neuronal differentiation.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
分子量antigen ~70 kDa
species reactivityrat, human
包装antibody small pack of 25 μL
浓度~1.0 mg/mL
technique(s)western blot: 1-2 μg/mL using rat brain extract (S1 fraction) and A431 cell lysate
UniProt登记号P49757
运输dry ice
储存温度−20℃
Gene Informationhuman ... NUMB(8650)
mouse ... Numb(18222)
rat ... Numb(29419)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号