产品说明
一般描述
The gene encoding NCK associated protein 1 (NAP-1) is localized on human chromosome 2q32 and is expressed in neuronal cells.
Nap1 is also known as Nap125, Nck-associated protein 1, NCKAP1 or histone chaperone NAP1. It is an essential component of this signaling complex. This gene is located on human chromosome 2q32. It is an important apoptosis-related gene.
应用
Anti-Nap1 (N-terminal) antibody produced in rabbit has been used in immunoblotting.
生化/生理作用
Nck-associated protein 1 (NAP1/NCKAP1) along with Sra1 and ABI1 (Abl interactor 1) is involved in stabilizing WAVE2. Removal of Nap1 or Sra1 by RNAi abrogated the formation of lamellipodia induced by growth factor. Nap1 interacts directly with Abi1. It has been shown that Nap1 mediates the interaction of the Nap1-PIR121 complex to Abi1. Nap1 may participates in neuronal cell death in Alzheimer′s disease (AD).
NCK associated protein 1 (NAP-1) has been shown to be downregulated in Alzheimer′s disease.
目标描述
Nap1 (N-terminal) interacts with Nck and may be involved in the downstream signaling of Nck [RGD].
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~125 kDa |
| species reactivity | mouse, human, rat |
| 增强验证 | recombinant expression Learn more about Antibody Enhanced Validation |
| 浓度 | ~1 mg/mL |
| technique(s) | western blot: 0.5-1 μg/mL using 3T3 cells lysate and HEK-293T cells expressing human Nap1 |
| UniProt登记号 | Q9Y2A7 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... NCKAP1(10787) mouse ... Nckap1(50884) rat ... Nckap1(58823) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
