产品说明
一般描述
A platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Reported to sensitize glioma cells to TNF-α-induced apoptosis.
Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.
A platinum coordination complex with potent antineoplastic activity.
Note: Athough highly soluble in DMSO, Cisplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Sodium chloride solution in water (154 mM NaCl with or without 10 mg/ml mannitol) or PBS (with 140 mM NaCl) is recommended for solubilization prior to culture treatment.
包装
50 mg in Glass bottle
生化/生理作用
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Induces apoptosis in cancer cells
警告
Toxicity: Toxic & Carcinogenic / Teratogenic (G)
重悬
Unstable in solution; reconstitute just prior to use.
其他说明
Hall, M.D., et al. 2014. Cancer Res. In press.
Duan, L., et al. 2001. J. Neurooncol.52, 23.
Mese, H., et al. 2000. Cancer Chemother. Pharmacol. 46, 241.
Von Hoff, D.D., and Rozencweig, M. 1979. in Adv. Pharmacol. Chemother.16, 279.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 线性分子式 | Pt(NH3)2Cl2 |
| MDL编号 | MFCD00011623 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze |
| 颜色 | yellow |
| 溶解性 | PBS with 140 mM NaCl: 1 mg/mL water with 154 mM NaCl: 1 mg/mL DMSO: 10 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
| InChI | 1S/2Cl.2H3N.Pt/h;;2*1H3; |
| InChI key | JFUARQHXOQHNLK-UHFFFAOYSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Danger |
| 危险声明 | H300 - H315 - H317 - H319 - H334 - H335 - H350 |
| 预防措施声明 | P202 - P261 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
