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5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole-CAS 53-85-0-Calbiochem

品牌
Sigma-Aldrich
CAS
53-85-0
货号
287891
规格纯度
A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC50 = 6 μM).
参考价格
2165.23 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Accentuates premature termination of transcription close to the promoter. Useful for isolation of RNA sequences near promoter sites that are responsible for mRNA formation. Useful for reversible superinduction of human fibroblast cultures. Potent, ATP-competivie and specific inhibitor of casein kinase II (IC50 = 6 µM). Has been used to inhibit RNA polymerase II transcription, which may be dependent on casein kinase II. Inhibits germinal vesicle breakdown in bovine oocytes.
A potent, ATP-competitive, and specific inhibitor of casein kinase II (IC50 = 6 µM). Reported to inhibit insulin-stimulated nuclear and cytosolic p70S6 kinase in CHO cells. Accentuates premature termination of transcription. Has been used to inhibit RNA polymerase II transcription which may be dependent on casein kinase II. Inhibits germinal vesicle breakdown in bovine oocytes. Induces G1/S cell cycle arrest.

包装

50 mg in Plastic ampoule

生化/生理作用

Primary Target
casein kinase II
Reversible: no
Product competes with ATP.
Cell permeable: no

警告

Toxicity: Standard Handling (A)

制备说明

May require warming (47°C) to achieve complete dissolution.

重悬

Room temperature (+20°C). Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Ethanol stock solutions are stable for up to 6 weeks at 4°C or for up to 3 months at -20°C.

其他说明

Kim., S.J., and Kahn, C.R. 1997. Biochem. Biophys. Res. Commun. 234, 681.
Farin, C.E., and Yang, L. 1994. Mol. Reprod. Dev.37, 284.
Giardina, C., and Lis, J.T. 1993. J. Biol. Chem. 268, 23806.
Zandomeni, R., et al. 1986. J. Biol. Chem.261, 3414.
Mittleman, B., et al. 1983. J. Mol. Biol. 165, 461.
Zandomeni, R., et al. 1983. J. Mol. Biol. 167, 561.
Zandomeni, R., et al. 1982. Proc. Natl. Acad. Sci. USA79, 3167.
Stewart, M.W., et al. 1977. J. Gen. Virol.37, 221.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C12H12Cl2N2O4
分子量319.14
MDL编号MFCD00036785

产品性质

质量水平100
测定≥98% (TLC)
形式solid
效能6 μM IC50
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
颜色 white
溶解性DMSO: 3 mg/mL
ethanol: 3 mg/mL
运输ambient
储存温度10-30℃
InChI1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1
InChI keyXHSQDZXAVJRBMX-DDHJBXDOSA-N

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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