Anti-Matrix Metalloproteinase-25, Propeptide Region antibody produced in rabbit

产品说明

一般描述

Matrix metalloproteinase-25 (MMP-25) belongs to the membrane-anchored matrix metalloproteinase subfamily. It is produced as a 57-60kDa monomer and is later expressed as a homodimer of 120kDa. This glycophosphatidylinositol (GPI)-anchored metalloproteinase is expressed in the polymorphonuclear neutrophils. MMP-25 possesses an extracellular prodomain along with other functional domains. The gene encoding it is localized on human chromosome 16p13.3.

特异性

By immunoblotting against the reduced protein, the antibody identifies a band at 65 kDa as well as breakdown products. The antibody recognizes the zymogen and not activated forms of the enzyme.

免疫原

synthetic peptide corresponding to the propeptide region of human matrix metalloproteinase-25 (membrane-type matrix metalloproteinase-6).

生化/生理作用

Matrix metalloproteinase-25 (MMP-25) acts as a marker for chronic respiratory diseases. Studies have indicated that MMP-25 can degrade fibrin, fibronectin, gelatin and type IV collagen. It may have a role in the degradation of the pericellular extracellular matrix.

外形

Solution in 0.01 M phosphate buffered saline containing 50% glycerol and 0.05% sodium azide.

基本信息

产品性质