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MEK1 (EE), active, GST tagged from mouse

品牌
Sigma-Aldrich
货号
M8697
规格纯度
PRECISIO® Kinase, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
参考价格
5924.03 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Mitogen-activated protein kinases 1 (MEK1) is encoded by the gene mapped to human chromosome 15q22.31 and the gene contains 11 exons with intervening sequences. MEK1 belongs to the MEK protein family and members of this family contain kinase domain at their amino-terminal and a catalytic domain at their carboxyl-terminal end.

生化/生理作用

Mitogen-activated protein kinase 1 (MEK1) participates in MAPK/ ERK (extracellular signal-regulated kinases) pathway, which plays a vital role in regulation of cell proliferation, differentiation and survival. Mutation of MEK1 gene leads to non-small cell lung cancer (NSCLC). In addition, aberrations of the gene is also observed in adenocarcinoma patients with current or former smoking status. MEK1 influences ERK activation in MAPK pathway and induce proliferation and anti-apoptotic signals. MEK1 facilitates platinum resistance via activation of excision repair cross-complementation group 1 (ERCC1) protein. Clinical trials show that, Trametinib acts as a MEK1/MEK2 inhibitor and is used to treat various cancers caused by MEK1 mutation including melanoma, colorectal cancer.

外形

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

法律信息

PRECISIO is a registered trademark of sigma-aldrich Co. LLC

基本信息

NACRESNA.32

产品性质

质量水平200
重组expressed in E. coli
产品线PRECISIO® Kinase
测定≥70% (SDS-PAGE)
形式buffered aqueous glycerol solution
specific activity276-374 nmol/min·mg
分子量 ~69 kDa
UniProt登记号P31938
运输dry ice
储存温度−70℃
Gene Informationmouse ... Map2k1(26395)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Sigma-Aldrich

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