产品说明
一般描述
Mitogen-activated protein kinases 1 (MEK1) is encoded by the gene mapped to human chromosome 15q22.31 and the gene contains 11 exons with intervening sequences. MEK1 belongs to the MEK protein family and members of this family contain kinase domain at their amino-terminal and a catalytic domain at their carboxyl-terminal end.
生化/生理作用
Mitogen-activated protein kinase 1 (MEK1) participates in MAPK/ ERK (extracellular signal-regulated kinases) pathway, which plays a vital role in regulation of cell proliferation, differentiation and survival. Mutation of MEK1 gene leads to non-small cell lung cancer (NSCLC). In addition, aberrations of the gene is also observed in adenocarcinoma patients with current or former smoking status. MEK1 influences ERK activation in MAPK pathway and induce proliferation and anti-apoptotic signals. MEK1 facilitates platinum resistance via activation of excision repair cross-complementation group 1 (ERCC1) protein. Clinical trials show that, Trametinib acts as a MEK1/MEK2 inhibitor and is used to treat various cancers caused by MEK1 mutation including melanoma, colorectal cancer.
外形
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
法律信息
PRECISIO is a registered trademark of sigma-aldrich Co. LLC
基本信息
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in E. coli |
| 产品线 | PRECISIO® Kinase |
| 测定 | ≥70% (SDS-PAGE) |
| 形式 | buffered aqueous glycerol solution |
| specific activity | 276-374 nmol/min·mg |
| 分子量 | ~69 kDa |
| UniProt登记号 | P31938 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | mouse ... Map2k1(26395) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
