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CLK4 Protein, active, 10 μg

品牌
Sigma-Aldrich
货号
14-917-M
规格纯度
Active, N-terminal 6His-tagged, recombinant, human CLK4, amino acids 128-end, for use in Kinase Assays.
参考价格
5865.39 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Product Source: N-terminal 6His-tagged, recombinant, human CLK4 amino acids 128-end expressed by baculovirus in Sf21 insect cells.
CLK4 protein belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined.

应用

Research Category
Signaling

生化/生理作用

Target Sub-Family: CMGC
Protein Target: CLK4

包装

Also available in 250μg size as catalog # 14-917M and in bulk as catalog # 14-917-K.

质量

Routinely evaluated by phosphorylation of peptide YRRAAVPPSPSLSRHSSPHQS(p)EDEEE.

外形

Purified using immobilized metal affinity chromatography.
50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol.

储存及稳定性

6 months at -70°C

其他说明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160405
NACRESNA.32

产品性质

质量水平300
100
生物来源human
分子量Mw 46 kDa
manufacturer/tradenameUpstate®
technique(s)activity assay: suitable (kinase)
NCBI登记号NM_020666
UniProt登记号Q9HAZ1

安全信息

象形图GHS07
警示用语:Warning
危险声明H317
预防措施声明P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
危险分类Skin Sens. 1
储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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