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ErbB2, active

品牌
Sigma-Aldrich
货号
14-939-M
包装型号
规格纯度
参考价格
7211.57 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization

应用

Research Category
Signaling

生化/生理作用

Protein Target: ErbB2
Target Sub-Family: TK

包装

Also available in 250μg size as catalog # 14-939M and in bulk as catalog # 14-939-K.

质量

Routinely evaluated by phosphorylation of poly(Glu, Tyr) (4:1)

外形

Purified using immobilized metal affinity chromatography.
Protein in 50mM Tris/HCl pH7.5, 150mM NaCl, 0.5mM EDTA, 0.01% CHAPS, 50% glycerol, 2mM DTT. Frozen solution.

储存及稳定性

6 months at -70°C

其他说明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160405
NACRESNA.32

产品性质

质量水平100
生物来源human
分子量Mw 69 kDa
manufacturer/tradenameUpstate®
technique(s)activity assay: suitable (kinase)
NCBI登记号NM_004448 (G778D)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2

Sigma-Aldrich

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