产品说明
一般描述
Studies demonstrate that Fibroblast Growth Hormone-23 plays a critical role as a phosphate-regulating hormone. FGF-23 is responsible for the inhibition of renal tubular reabsorption of inorganic phosphorus and, consequently, the regulation of phosphorus homeostasis. FGF-23 mRNA is expressed in the brain, in the thymus at low levels, in dendritic cells, with the highest expression in osteocytes and osteoblasts during phases of active bone remodeling. Because circulating levels of FGF-23 are regulated by vitamin D and phosphorus, normal skeletal and soft tissue development require vitamin D and a functional vitamin D signaling pathway. Diseases resulting from aberrant FGF-23 expression include inherited forms of rickets, certain kidney diseases and phosphorus-related tumors.
特异性
The antibody pair used in this assay cross-reacts 0.01% to Human FGF- 21 and 0.01% to FGF-19.
No significant cross-reactivity has been observed to other human and rat molecules/hormones tested
应用
Research Category
Stem Cell Research
50µl sample size, 2-Step assay with <4hr incubation time.
Used to detect/quantify: FGF-23
其他说明
Please contact Technical Service for linearity of dilution.
免责声明
For research use only. Not for use in diagnostic procedures.
基本信息
| eCl@ss | 32161000 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 100 |
| species reactivity | human |
| assay range | sensitivity: 9.9 pg/mL (minimum detectable concentrations in tissue culture/serum/plasma) standard curve range: 9.9-2400 pg/mL inter-assay cv: <11% intra-assay cv: <11% |
| technique(s) | ELISA: suitable |
| detection method | colorimetric fluorometric |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
