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Lipopolysaccharides from Salmonella enterica serotype minnesota

脂多糖 来源于肠沙门氏菌 明尼苏达血清型

品牌
Sigma-Aldrich
货号
L6261
规格纯度
purified by phenol extraction
参考价格
1814.95 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Lipopolysaccharide (LPS) is the pyrogenic element arising from enterobacteria such as Escherichia coli and Salmonella enterica. It is an amphiphilic component containing polysaccharides and lipoidic material. LPS is present in the outer membrane of the cell wall of almost all Gram-negative bacteria.
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

应用

Lipopolysaccharides from Salmonella enterica serotype minnesota has been used:

  • as a toll-like receptors (TLR ) agonist to induce tumor necrosis factor (TNF) α production in cereblon and Rabex-5 deficient mice in vivo,
  • to study its effect on prostaglandin-E Synthase (PTGES) protein expression in monocyte-derived macrophages
  • as a positive control for the maturation of monocyte-derived dendritic cells (MoDCs) to assess secretion of interleukin-10 and interferon (IFN)-γ
  • as a supplement in Roswell park memorial institute (RPMI)media for culturing splenic B cells
  • as a toll-like receptor 4 ligand to study its effect on the expression of the proallergic cytokines thymic stromal lymphopoietin (TSLP) and interleukin 33 (IL33) in H292 cells (pulmonary mucoepidermoid carcinoma cells)

生化/生理作用

Lipopolysaccharide (LPS) forms a permeability barrier around the cell surface to restrict the entry of toxic molecules such as antibiotics and bile salts. Owing to their external location, this endotoxin also plays a vital role in host-bacterium interactions by regulating host immune response. LPS is a microbe-associated molecular pattern (MAMP) that serves as a potent agonist for toll-like receptor 4 (TLR4)-MD2-CD14 receptor complex.

基本信息

MDL编号MFCD00131520
NACRESNA.83

产品性质

形式lyophilized powder
质量水平200
纯化方式phenol extraction
杂质<3% Protein (Lowry)
储存温度2-8℃

安全信息

象形图GHS06
警示用语:Danger
危险声明H300
预防措施声明P264 - P270 - P301 + P310 + P330 - P405 - P501
危险分类Acute Tox. 2 Oral
储存分类代码6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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