产品说明
一般描述
Guanosine 5′-diphosphate (GDP) is a purine nucleotide and is interconvertible to guanosine by the action of ectonucleotidases and by nucleoside phosphorylase into guanine. GDP is majorly acted upon by 5′‐ectonucleotidases in neuronal cells.
应用
Guanosine 5′-diphosphate disodium salt has been used:
- in fluorescent metal nanoclusters selectivity of guanosine 3′-diphosphate-5′-di(tri)phosphate, ppGpp
- in screening of fluorescence emission of hypocrellin A-zinc complex
- as a component of assay buffers in the autoradiography of mice brain sections
Guanosine 5′-diphosphate (GDP) is used as a substrate of pyruvate kinase to produce GTP in support of RNA biosyntheis. GDP is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). GDP is also used to study cell signaling processes mediate by guanine nucleotide exchange factors.
生化/生理作用
Guanosine based nucleosides play a key role in multiple cellular processes and generation growth factors. Elevated levels of guanosine 5′-diphosphate (GDP) is associated with the pathogenesis of neurological disorders. GDP is bound to G protein . G protein coupled receptors (GPCRs) activate G proteins by exchanging the bound GDP to GTP. GDP is potent inhibitor agent of hepcidin- ferroportin complex and may be effective for promoting erythropoiesis and treating anemia of inflammation(AI).
基本信息
| 经验(实验)分子式 | C10H13N5Na2O11P2 |
| 分子量 | 487.16 |
| EC 号 | 231-026-2 |
| MDL编号 | MFCD00084665 |
| PubChem化学物质编号 | 57651304 |
| NACRES | NA.51 |
产品性质
| 质量水平 | 100 |
| 生物来源 | Porcine brain microbial (Corynebacterium sp) synthetic |
| 测定 | ≥90% (HPLC) |
| 形式 | powder |
| 溶解性 | H2O: 50 mg/mL, clear, colorless |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| SMILES string | [Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1 |
| InChI | 1S/C10H15N5O11P2.2Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;/q;2*+1/p-2/t3-,5-,6-,9-;;/m1../s1 |
| InChI key | LTZCGDIGAHOTKN-LGVAUZIVSA-L |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
