产品说明
一般描述
IGF1R (insulin-like growth factor I) is a receptor tyrosine kinase. The gene is mapped to human chromosome 15q26. It is expressed in various solid tumors as well as hematologic malignancies.
应用
Insulin-like growth factor-I receptor human has been used to study the binding constants of estradiol to insulin, insulin receptors and insulin-like peptides.
生化/生理作用
IGF-I receptor, a tyrosine kinase receptor with signal transduction pathways, is comprised of two α and two β subunits. IGF-I receptor binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.
外形
Lyophilized from a 0.2 μm solution in phosphate buffered saline.
分析说明
The biological activity is measured by its ability to bind human IGF-I in a functional ELISA assay.
As a result of glycosylation in SDS-PAGE under reducing conditions, the recombinant α subunit migrates as a doublet of ~120 kDa and 150 kDa and the β subunit migrates as doublet of ~46 kDa and 50 kDa.
基本信息
| MDL编号 | MFCD01323726 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 生物来源 | human |
| 重组 | expressed in NSO cells |
| 测定 | ≥95% (SDS-PAGE) |
| 形式 | lyophilized powder |
| 分子量 | α-chain ~120 & 150 kDa β subunit ~46 & 50 kDa |
| 包装 | pkg of 50 μg |
| 杂质 | endotoxin, tested |
| UniProt登记号 | P08069 |
| 储存温度 | −20℃ |
| Gene Information | human ... IGF1R(3480) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
