产品说明
一般描述
Glucagon-Like Peptide 1 Receptor (GLP-1R) is the receptor for glucagon-like peptide 1 and is expressed in the pancreatic beta cells. Ligand binding activates adenyl-cyclase activity which results in increased insulin synthesis and release. GLP-1R is also expressed in the brain where it functions in the control of appetite, memory and learning. GLP-1R also has neuroprotective functions which may be beneficial in diseases such as Huntington′s disease, and drugs that are GLP-1R agonists (acts like natural ligand to activate the receptor) such as Exendin-4 are being examined as potential therapies for the disease as well as diabetes and other memory and metabolic disorders.
免疫原
Epitope: extracellular domain, near N-Terminus
KLH-conjugated linear peptide corresponding to the extracellular domain of Human Glucagon-Like Peptide 1 Receptor.
应用
Research Category
Metabolism
Signaling
This Anti-GLP1R Antibody is validated for use in Immunohistochemistry (Paraffin) for the detection of GLP1R.
Research Sub Category
Lipid Metabolism & Weight Regulation
Lipid Signaling
质量
Evaluated by Immunohistochemistry (Paraffin) on endocrine cells in human pancreas.
Immunohistochemistry Analysis: 2 ug/ml this antibody showed cytoplasmic staining of subsets of endocrine cells in islets of Langerhans in human pancreas.
目标描述
53 kDa calculated
联系
Replaces: AB9433
外形
Purified rabbit Polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Antigen Affinity Purified
储存及稳定性
Stable for 1 year at 2-8°C from date of receipt.
其他说明
Concentration: Please refer to lot specific datasheet.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 纯化方式 | affinity chromatography |
| species reactivity | mouse, human |
| technique(s) | immunohistochemistry: suitable (paraffin) |
| NCBI登记号 | NP_002053 |
| UniProt登记号 | P43220 |
| 运输 | wet ice |
| Gene Information | human ... GLP1R(2740) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
