产品说明

一般描述

Trimethyl(trifluoromethyl)silane (TMSCF₃) is also called as Ruppert-Prakash fluorination reagent. It is extensively used for the synthesis of trifluoromethyl-containing compounds.

应用

Reactant for:

• Silver-mediated C-H trifluoromethylation of arenes
• Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 8
• Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts
• Palladium-catalyzed oxidative trifluoromethylation of indoles
• Preparation of 5-HT1A antagonists

• Used as difluorocarbene source

TMSCF₃ can be used as a reagent for:

• Conversion of aromatic aldehydes to difluoromethylated products.
• C-H trifluoromethylation of arenes, terminal alkynes, tertiary amines, heteroarenes, allylic, and terminal alkenes using metal catalyst or metal free oxidative trifluoromethylation reaction.

It can also be used in trifluoromethylation of:

• Non-activated aldimines.
• Heterocumulenes.
• Azomethine imines.

包装

10, 50 mL in glass bottle

基本信息

线性分子式	(CH3)3SiCF3
分子量	142.19
Beilstein	4241868
MDL编号	MFCD00145454
PubChem化学物质编号	57653455
NACRES	NA.22

产品性质

形式	liquid
质量水平	100
reaction suitability	reaction type: C-C Bond Formation
浓度	2 M in THF
折射率	n20/D 1.386
密度	0.91 g/mL at 20 ℃
SMILES string	C[Si](C)(C)C(F)(F)F
InChI	1S/C4H9F3Si/c1-8(2,3)4(5,6)7/h1-3H3
InChI key	MWKJTNBSKNUMFN-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H225 - H302 - H319 - H335 - H351
预防措施声明	P210 - P280 - P301 + P312 + P330 - P305 + P351 + P338 - P370 + P378 - P403 + P235
危险分类	Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
靶器官	Respiratory system
补充剂危害	EUH019
储存分类代码	3 - Flammable liquids
WGK	WGK 3
闪点(F)	1.4 °F
闪点(C)	-17 ℃
个人防护装备	Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter