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Proguanil hydrochloride

氯胍 盐酸盐

品牌
Sigma-Aldrich
CAS
637-32-1
货号
G7048
规格纯度
≥95% (HPLC)
参考价格
1056.81 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.

包装

10, 50 mg in glass bottle

生化/生理作用

Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.

特点和优势

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式C11H16ClN5·HCl
分子量290.19
EC 号211-283-7
MDL编号MFCD01732193
PubChem化学物质编号329799959
NACRESNA.77

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
储存条件desiccated
溶解性acetonitrile: water: ~1 mg/mL (60/40)
创始人AstraZeneca
储存温度2-8℃
SMILES stringCl.CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1
InChI1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H
InChI keySARMGXPVOFNNNG-UHFFFAOYSA-N

安全信息

象形图GHS06
警示用语:Danger
危险声明H301
预防措施声明P301 + P310
危险分类Acute Tox. 3 Oral
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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