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Anti-GABAA Receptor (α1 subunit) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
G4416
规格纯度
affinity isolated antibody
参考价格
4053.29 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

GABAA and GABAB receptors differ with regard to their ionic characteristics and pharmacological properties. The GABAA receptor is an ionotropic receptor that forms the GABA gated chloride channel and consists of several heterogeneous subunits with membrane recognition sites for benzodiazapenes.

免疫原

peptide corresponding to amino acids 28-43 of rat GABA(A) receptor α1 subunit.

应用

Anti-GABAA Receptor (α1 subunit) antibody produced in rabbit is suitable for detection of GABA-A α1 subunit by immunohistochemistry using rat brain sections and by immunoblotting at a working dilution of 1:400-1:1000 using rat brain membranes.

生化/生理作用

The inhibitory neurotransmitter GABA signals through two distinct types of pre- and postsynaptic receptors, GABAA and GABAB. Both GABA receptors can regulate depression of synaptic transmission and be involved in the inhibition controlling neuronal excitability. α1 is a subtype of GABAA receptor expressed selectively by serotonergic and GABAergic neurons. Serotonergic neurons express strong α3 immunoreactivity but, do not show any α1 immunoreactivity. On the contrary, GABAergic neurons express both α1 and α3 subunits.

外形

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

制备说明

Reconstitute the 0.05 mL vial with 50 μL deionized water. Reconstitute the 0.2 mL vial with 0.2 mL deionized water. After reconstitution, the antibody concentration is ~0.8 mg/mL.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD01092338
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式lyophilized powder
分子量antigen ~50 kDa
species reactivityrat, bovine (predicted), mouse, chicken (predicted), human (predicted)
technique(s)immunohistochemistry: suitable using rat brain sections
western blot: 1:400-1:1,000 using rat brain membranes
UniProt登记号P14867
储存温度−20℃
Gene Informationhuman ... GABRA1(2554)
mouse ... Gabra1(14394)
rat ... Gabra1(29705)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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