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GROα human

品牌
Sigma-Aldrich
货号
G0657
规格纯度
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
参考价格
3324.46 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

GROα, also called CXCL1 (chemokine (C-X-C motif) ligand 1), is a member of the small soluble chemokine protein family. It belongs to the C-X-C subfamily, which is comprised of 17 members. It contains a conserved glutamic acid-leucine-arginine (ELR) domain. This protein is expressed on stromal cells such as, endothelial cells, fibroblasts and blood-circulating cells.

生化/生理作用

GROα, also called CXCL1 (chemokine (C-X-C motif) ligand 1), plays an essential role in neutrophil recruitment, and the initiation of angiogenesis. This gene is up-regulated in multiple cancer types such as, gastric cancer, renal cell carcinoma, prostate cancer and melanoma. The expression of this protein is also elevated in HER2 positive metastatic breast cancer. Its expression is increased in fibroblasts, which might be involved in breast tumor progression, and its stromal expression in breast cancer is linked to poor prognosis. This gene is also up-regulated in the aggressive phenotype of bladder cancer. Polymorphism rs4074 A in this gene is also associated with susceptibility to alcoholic cirrhosis.

外形

Lyophilized from a 0.2 μm filtered solution in 25% acetonitrile and 0.1% trifluoroacetic acid containing 50 μg bovine serum albumin per 1 μg of cytokine.

分析说明

The biological activity is measured by its ability to induce chemotaxis of mouse BaF/3 cells transfected with hCXCR2.

基本信息

EC 号200-835-2
MDL编号MFCD00677959
NACRESNA.32

产品性质

质量水平100
生物来源human
重组expressed in E. coli
测定≥97% (SDS-PAGE)
形式lyophilized powder
效能1.0-4.0 ng/mL
分子量 ~7.9 kDa
包装pkg of 10 μg
储存条件avoid repeated freeze/thaw cycles
technique(s)cell culture | mammalian: suitable
杂质 endotoxin, tested
UniProt登记号P09341
储存温度−20℃
Gene Informationhuman ... CXCL1(2919)

安全信息

象形图GHS02GHS07
警示用语:Danger
危险声明H225 - H302 + H312 + H332 - H319
预防措施声明P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
危险分类Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
储存分类代码3 - Flammable liquids
WGKWGK 2
闪点(F)35.6 °F - (Acetonitrile)
闪点(C)2.0 ℃ - (Acetonitrile)
个人防护装备Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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