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GBR 12935 dihydrochloride

品牌
Sigma-Aldrich
CAS
67469-81-2
货号
G9659
规格纯度
≥98% (TLC), powder
参考价格
2370.81 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

GBR 12935 dihydrochloride has been used as a dopamine reuptake inhibitor to study its effects on noradrenergic stimulation in the medial prefrontal cortex of rats (mPFC). It has also been used as a selective dopamine transporter (DAT) inhibitor to study its effects on behavior and neurochemical response in enriched condition (EC) and impoverished condition (IC) rats.

包装

25, 100 mg in poly bottle

生化/生理作用

GBR 12935 inhibits the dopamine and norepinephrine transporters with Kis of 21.5 nM and 225 nM, respectively. It does not inhibit the serotonin transporter (Ki = 6.5 mM). GBR 12935 binds to a nondopaminergic piperazine site in blood platelets and brain that has been identified as cytochrome P450.

特点和优势

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式C28H34N2O · 2HCl
分子量487.50
MDL编号MFCD00083175
PubChem化学物质编号24277959
NACRESNA.77

产品性质

质量水平200
测定≥98% (TLC)
形式powder
颜色 white
溶解性H2O: 20 mg/mL (with warming)
SMILES stringCl[H].Cl[H].C(CN1CCN(CCOC(c2ccccc2)c3ccccc3)CC1)Cc4ccccc4
InChI1S/C28H34N2O.2ClH/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27;;/h1-9,11-12,14-17,28H,10,13,18-24H2;2*1H
InChI keyNQWRSILGEXNJIT-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

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