产品说明
包装
5, 25 mg in glass bottle
生化/生理作用
δ-GABAA receptors are emerging as an important pharmacological target. DS1 potently (low nM) enhances GABA-evoked currents mediated by α4β3δ receptors. It had little effect on GABA responses mediated by α4β3γ2 receptors. At similar concentrations DS1 directly activates this receptor and is the most potent known agonist of α4β3δ receptors. This compound has an opportunity to be become an agonist golden stardard for δ-GABAA receptors.
DS1 potently (low nM) enhances GABA-evoked currents mediated by GABAA α4β3δ receptor subtype. At similar concentrations, it acts as a direct agonist at this receptor and is the most potent agonist known. It has little effect on GABA responses mediated by α4β3γ2 receptors.
基本信息
| 经验(实验)分子式 | C18H10Br2ClN3OS |
| 分子量 | 511.62 |
| MDL编号 | MFCD01943217 |
| PubChem化学物质编号 | 329798608 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 储存条件 | desiccated |
| 颜色 | off-white to tan |
| 溶解性 | DMSO: >10 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | Clc1ccc(cc1)C(=O)Nc2c(nc3c(Br)cc(Br)cn23)-c4cccs4 |
| InChI | 1S/C18H10Br2ClN3OS/c19-11-8-13(20)16-22-15(14-2-1-7-26-14)17(24(16)9-11)23-18(25)10-3-5-12(21)6-4-10/h1-9H,(H,23,25) |
| InChI key | MEWSBNIVOLYKGU-UHFFFAOYSA-N |
