Cystatin C, Human Urine-Calbiochem

产品说明

一般描述

A low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that it is freely filtered by the glomerular membrane. Serum levels of cystatin C can be used as a specific and sensitive marker of glomerular filtration rate. Protects organisms against undesirable proteolysis by endogenous or exogenous enzymes. Thought to be linked to many disease processes including Alzheimer’s disease, hereditary cerebral hemorrhage, and lung cancer.
A low molecular weight non-glycosylated basic protein of the cystatin superfamily of cysteine protease inhibitors that is freely filtered by the glomerular membrane. Serum levels of cystatin C can be used as a specific and sensitive marker of glomerular filtration rate. Protects organisms against undesirable proteolysis by endogenous or exogenous enzymes. Rapidly and tightly inhibits papain (K_i = 0.26 nM) and cathepsin B (K_i = 4.4 nM). Thought to be linked to many disease processes including Alzheimer′s Disease, hereditary cerebral hemorrhage and lung cancer.

包装

50 μg in Plastic ampoule

生化/生理作用

Primary Target
Cysteine protease
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

外形

Lyophilized from 20 mM NH₄HCO₃.

制备说明

Prepared from the urine of patients with chronic renal tubular proteinuria that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

重悬

Following reconstitution, store in the refrigerator at 4°C. Stock solutions are stable for up to 2 month when stored at -20°C.

其他说明

Hall, A., et al. 1998. Biochemistry37, 4071.
Peloille, S., et al. 1997. Eur. J. Biochem. 244, 140.
Cimerman, N., et al. 1996. Biol. Chem. Hoppe Seyler 377, 19.
Tenstad, O., et al. 1996. Scand. J. Clin. Lab. Invest.56, 409.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

产品性质

安全信息