产品说明
包装
5, 25 mg in glass bottle
生化/生理作用
DPO-1 is an inhibitor of human Kv1.5 potassium channel; representative blocker of a novel pharmacophore. The Kv1.5 potassium channel, which underlies the ultrarapid delayed rectifier current, IKur, is reported to be enriched in human atrium versus ventricle, and has been proposed as a target for novel atrial antiarrhythmic therapy. The administration of the IKur blocker (2-isopropyl-5-methyl-cyclohexyl) diphenylphosphine oxide (DPO-1) increases myocardial refractoriness in both atrium and ventricle of rat, but produces an atrial-selective increase in refractoriness in primates; appears to be 15-fold more selective for Kv1.5 vs Kv3.1 channels expressed in Xenopus oocytes. IC50 = 0.16-0.76 μM at 0.1 Hz pulsing frequency; Kd = 0.6 μM.
特点和优势
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
基本信息
| 经验(实验)分子式 | C22H29OP |
| 分子量 | 340.44 |
| MDL编号 | MFCD09038567 |
| PubChem化学物质编号 | 329798851 |
| NACRES | NA.77 |
产品性质
| 测定 | >97% (NMR) |
| 形式 | needles |
| 储存条件 | protect from light |
| 颜色 | white |
| 溶解性 | DMSO: 2 mg/mL, clear (warmed) |
| 储存温度 | 2-8℃ |
| SMILES string | CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1P(=O)(c2ccccc2)c3ccccc3 |
| InChI | 1S/C22H29OP/c1-17(2)21-15-14-18(3)16-22(21)24(23,19-10-6-4-7-11-19)20-12-8-5-9-13-20/h4-13,17-18,21-22H,14-16H2,1-3H3/t18-,21+,22+/m1/s1 |
| InChI key | BPCNGVCAHAIZEE-COPCDDAFSA-N |
