产品说明
一般描述
The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.
应用
This armenian hamster monoclonal Anti-CD152 (CTLA-4) Antibody (mouse), PE-Cy7, clone UC10-4F10-11, Cat. No. MABF1586 is validated for use in Flow Cytometry, for the detection of CD152 (CTLA-4).
质量
This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.
Flow Cytometry Analysis: 0.125 μg from a representative lot detected CD152 (CTLA-4) in one million C57Bl/6 splenocytes.
外形
Purified by size-exclusion chromatography
其他说明
Concentration: Please refer to lot specific datasheet.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.44 |
产品性质
| 生物来源 | hamster (Armenian) |
| 质量水平 | 100 |
| 偶联物 | PE-Cy7 |
| 抗体形式 | purified antibody |
| antibody product type | primary antibodies |
| 克隆 | UC10-4F10-11, monoclonal |
| species reactivity | mouse |
| 包装 | antibody small pack of 25 μg |
| technique(s) | flow cytometry: suitable |
| 同位素/亚型 | IgG |
| UniProt登记号 | P09793 |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
