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Anti-CSTF1 (C-terminal) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
C2372
规格纯度
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
参考价格
4731.57 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Cleavage stimulation factor 1 (CSTF1) contains seven WD-40 repeats. The CSTF1 gene is mapped to human chromosome 20q13.2-q13.31.

特异性

Anti-CSTF1 (C-terminal) specifically recognizes human CSTF1 (also known as Cleavage stimulation factor).

应用

Anti-CSTF1 (C-terminal) antibody produced in rabbit is suitable for immunoprecipitation at a working amount of 5-10μg using K562 lysates and western blotting at a concentration of 2-4μg/mL using K562 lysates.

生化/生理作用

Cleavage stimulation factor (50kDa) subunit is a protein encoded by the CSTF1 gene in humans. It is one of the multiple factors that plays a significant role during polyadenylation of mammalian pre-mRNAs. The mRNA polyadenylation factor CstF interacts with the BRCA1-associated protein BARD1 resulting in repression of the nuclear mRNA polyadenylation machinery. It participates in the regulation of endogenous transcripts during DNA-damage.
CSTF1 is required for in vitro cleavage activity. The WD-40 repeats are crucial for the interaction with CSTF3. CSTF1 also interacts directly with the RNA polymerase II CTD, suggesting a role in linking transcription and mRNA 3′-ends processing.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

储存及稳定性

Store at –20 ℃. For continuous use, the product may be stored at 2–8 ℃ for up to one month. For extended storage, freeze in working aliquots at –20 ℃. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen ~48 kDa
species reactivityhuman
浓度~1 mg/mL
technique(s)immunoprecipitation (IP): 5-10 μg using K562 lysates
western blot: 2-4 μg/mL using K562 lysates
UniProt登记号Q05048
运输dry ice
储存温度−20℃
Gene Informationhuman ... CSTF1(1477)
mouse ... Cstf1(67337)
rat ... Cstf1(311670)

Sigma-Aldrich

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