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Insulin-Like Growth Factor Binding Protein-3 human

品牌
Sigma-Aldrich
货号
I5278
规格纯度
recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)
参考价格
8114.65 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Human IGFBP-3 is the major insulin-like growth factor (IGF) binding protein in plasma, where it exists in a ternary complex with IGF-I or IGF-II and the acid-labile subunit (ALS).
IGFBPs (insulin like growth factor binding proteins) regulate bioavailability of IGFs (insulin like growth factors) in cells. Binding between IGFs and IGFBPs reduces the availability of the IGFs. However, IGFBPs also concentrate IGFs in specific areas to potentiate their effects at right time. IGFBP3 binds to IGF-1. It is a tumor suppressor and is downregulated in many cancers. In serum, IGFs, IGFBP3 and the acid labile subunit (ALS) exist together as a complex. This complex is important for increasing the half life of serum IGFs.

外形

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA.

分析说明

The biological acitivity is measured as the ability to inhibit the biological activity of 14 ng/ml recombinant human IGF-I on MCF-7 cells.

基本信息

MDL编号MFCD00285941
NACRESNA.32

产品性质

质量水平100
生物来源human
重组expressed in NSO cells
测定≥95% (SDS-PAGE)
形式lyophilized powder
效能0.01-0.25 μg/mL
分子量 29 kDa
包装pkg of 25 μg
储存条件avoid repeated freeze/thaw cycles
technique(s)cell culture | mammalian: suitable
杂质 endotoxin, tested
UniProt登记号P17936
储存温度−20℃
Gene Informationhuman ... IGFBP3(3486)

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 + H312 + H332 - H319
预防措施声明P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
危险分类Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码3 - Flammable liquids
WGKWGK 2
个人防护装备dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Sigma-Aldrich

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