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Nateglinide

那格列奈

品牌
Sigma-Aldrich
CAS
105816-04-4
货号
N3538
规格纯度
≥98% (HPLC), solid
参考价格
2475.02 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

10, 50 mg in glass bottle

生化/生理作用

Nateglinide is a Kir6.2/SUR1 channel inhibitor and antidiabetic. It is selective for the SUR1 subtype, which is found on pancreatic islet cells. Nateglinide evokes KATP channel-dependent insulin secretion (50-200 μM) in the absence and presence of insulin.
Nateglinide is a short-acting insulin secretagogue useful in treating type 2 diabetes. It is an insulinotropic agent effective for postprandial hyperglycemia. Nateglinide restores prandial insulin levels in a glucose-dependent manner.

特点和优势

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式C19H27NO3
分子量317.42
MDL编号MFCD00875706
PubChem化学物质编号329818636

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
颜色 white to off-white
溶解性DMSO: >5 mg/mL
H2O: insoluble
创始人Novartis
储存温度room temp
SMILES stringCC(C)[C@@H]1CC[C@H](CC1)C(=O)N[C@H](Cc2ccccc2)C(O)=O
InChI1S/C19H27NO3/c1-13(2)15-8-10-16(11-9-15)18(21)20-17(19(22)23)12-14-6-4-3-5-7-14/h3-7,13,15-17H,8-12H2,1-2H3,(H,20,21)(H,22,23)/t15-,16-,17-/m1/s1
InChI keyOELFLUMRDSZNSF-BRWVUGGUSA-N
Gene Informationhuman ... ABCC8(6833), KCNJ11(3767)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

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