产品介绍：
产品说明
一般描述
BL-1249 is a non-steroid anti-inflammatory drug and an inhibitor of the cyclooxygenase (COX) enzyme.
应用
BL-1249 has been used:
- as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissues
- as a TWIK related potassium channel (TREK2) modulator and in U-2 OS osteosarcoma cell line
- as a TREK1 and TREK2 activator in mice.
包装
10, 50 mg in glass bottle
生化/生理作用
BL-1249 also activates TWIK related potassium channel 2 (TREK2). It interacts with K2P channel at the negatively charged activator site and modulates channel opening.
BL-1249 is a putative activator of potassium TREK-1 channel.
特点和优势
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
基本信息
| 经验(实验)分子式 | C17H17N5 |
| 分子量 | 291.35 |
| MDL编号 | MFCD08276915 |
| PubChem化学物质编号 | 24724415 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| 储存条件 | protect from light |
| 颜色 | pink to brown |
| 溶解性 | DMSO: ~17.5 mg/mL H2O: insoluble |
| 储存温度 | −20℃ |
| SMILES string | C1CCc2c(C1)cccc2Nc3ccccc3-c4nnn[nH]4 |
| InChI | 1S/C17H17N5/c1-2-8-13-12(6-1)7-5-11-15(13)18-16-10-4-3-9-14(16)17-19-21-22-20-17/h3-5,7,9-11,18H,1-2,6,8H2,(H,19,20,21,22) |
| InChI key | YYNRZIFBTOUICE-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H315 - H319 - H335 - H413 |
| 预防措施声明 | P273 - P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
