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Human Osteoblasts: HOb, adult

品牌
Sigma-Aldrich
货号
406-05A
包装型号
规格纯度
参考价格
11789.3 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

HOb are isolated from fetal or adult human bones. Additionally, osteoblasts from osteoarthritis or rheumatoid arthritis donors are available. Human osteoblasts provide an excellent model system for studies relevant to the skeletal system.

Characterization: Positive for bone mineralization.

Human osteoblasts have been used to:

  • Characterize signaling pathways mediating bone morphogenesis, such as identify human Crossveinless-2 as an inhibitor of BMP (Binnerts, 2009); demonstrate crosstalk between Runx2, Osterix, and NELL-1 (Chen, 2011); identify TWEAK as a cytokine regulating RANTES production, BMP-2-induced differentiation, and RANKL expression in osteoblasts (Ando, 2006)
  • Demonstrate that Kobophenol A enhances proliferation of osteoblasts via activation of the p38 pathway (Kwak, 2013) and clarify the relationship between hypertension and osteoporosis by demonstrating that Ang II activates osteoclasts via RANKL induction (Shimizu, 2008, 2012)
  • Identify adiponectin as an activator of IL-6, IL-8, VEGF and MMPs in endothelial cells and osteoblasts, implicating it in the development of arthritis (Lee, 2014)
  • Show that inhibition of NF-κB prevented the progression of bone loss in periodontitis and promoted the wound healing in bone defects through the inhibition of osteoclasts (Shimizu, 2009)
  • Study active compounds from Uraria crinita for their potential to stimulate bone formation and regeneration (Mao, 2014)
  • Investigate properties of osteosarcoma, including the role of fluid pressure in angiogenesis (Nathan, 2008) and novel oncogenes (Both, 2012); and develop better treatment strategies (Ma, 2011)
  • Develop optimal materials, coatings and drug delivery techniques for orthopedic implants and tissue engineering (Frandsen, 2014; Ni, 2012; Pilia, 2013a, b, 2014; Shiels, 2012; Valente, 2012; Zhang, 2010, 2011)

细胞系来源

Bone

应用

model for skeletal system research, signaling pathways, bone morphogenesis, gene expression, cell activation and proliferation, wound healing, bone formation and regeneration, treatment strategies, tissue engineering, in vitro bone models, mineralization, hormone treatments

组分

Basal Medium containing 10% FBS & 10% DMSO

制备说明

  • 2nd passage, >500,000 cells in Basal Medium containing 10% FBS & 10% DMSO
  • Can be cultured at least 10 doublings

传代培养常规

Please refer to the HOb Culture Protocol.

基本信息

NACRESNA.81

产品性质

生物来源human bone (normal)
包装pkg of 500,000 cells
生长模式Adherent
核型2n = 46
形态学osteoblast
technique(s)cell culture | mammalian: suitable
相关疾病arthritis; osteoporosis
运输dry ice
储存温度−196℃

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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